Department of Medicine
Cellular signaling and epigenetic mechanisms in B cell lymphoma
The major research focus of Dr. Rui’s laboratory is on mechanisms of B-cell receptor and JAK-STAT signaling pathways and epigenetic enzymes, including protein arginine methyltransferase 5 (PRMT5) and DNA methyltransferases (DNMTs), in lymphomagenesis. His research team employs a multidisciplinary approach, using biochemistry, RNA interference, genomic technologies, CRISPR/Cas9 and systems biology methods, to identify mechanisms downstream of the B-cell receptor and JAK-STAT signaling pathways and establish the function of these epigenetic enzymes in B cell lymphoma. The goal of his research is to discover molecular targets in these pathways for therapeutic, diagnostic and prognostic development of B cell lymphoma.