GATA2 Mechanisms and Pathology
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GATA2 Mechanisms and Pathology


This page will serve as a resource to learn about the GATA2 transcription factor – specifically, how it controls blood stem and progenitor cell development and function, how human genetic variation alters GATA2 activity, and how GATA2 deregulation creates a predisposition to the development of Myelodysplastic Syndromes and Acute Myeloid Leukemia. GATA2 can be deregulated through germline (inherited) genetic variation, acquired genetic variation in somatic cells, and/or epigenetic alterations that alters GATA2 gene activity without changing its DNA sequence.


For further information, contact Dr Emery Bresnick:


This page is UNDER CONSTRUCTION. More information to follow.