Ci Ji Lim, PhD
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Discovery Spotlight

Ci Ji Lim, PhD

 

Assistant Professor
Department of Biochemistry

 

Molecular mechanisms of human telomere maintenance and associated diseases.

 

Telomeres are repetitive DNA and associated proteins at the ends of linear chromosomes. They protect our chromosome ends from being misread as broken ends, underlining the importance of telomeres for genome stability. They also serve as a “clock” for our biological lifespan. The Lim lab seeks to investigate the molecular mechanisms of human telomere maintenance using an interdisciplinary approach. This includes structural studies using cryo-electron microscopy (cryo-EM) and spatial/temporal studies at the chromatin level using single-molecule techniques. Specifically, the Lim lab focuses on two major areas: 1) Telomere chromatin organization and 2) Telomere replication mechanism.

 

Publications:
https://www.ncbi.nlm.nih.gov/myncbi/ci%20ji.lim.1/bibliography/public/