Lixin Rui
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Discovery Spotlight

Lixin Rui, PhD


Associate Professor
Department of Medicine


Cellular signaling and epigenetic mechanisms in B cell lymphoma


The major research focus of Dr. Rui’s laboratory is on mechanisms of B-cell receptor and JAK-STAT signaling pathways and epigenetic enzymes, including protein arginine methyltransferase 5 (PRMT5) and DNA methyltransferases (DNMTs), in lymphomagenesis. His research team employs a multidisciplinary approach, using biochemistry, RNA interference, genomic technologies, CRISPR/Cas9 and systems biology methods, to identify mechanisms downstream of the B-cell receptor and JAK-STAT signaling pathways and establish the function of these epigenetic enzymes in B cell lymphoma. The goal of his research is to discover molecular targets in these pathways for therapeutic, diagnostic and prognostic development of B cell lymphoma.